18F-PSMA-1007 Uptake in Paget Disease of the Bone: An "Iron Man" Sign. (March 2022)

• Record Type: Journal Article
• Authors: Alfeeli, Mahamoud; Marafi, Fahad; Esmail, Abdulredha; Fathallah, Wael M.A.; Usmani, Sharjeel
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 3(2022)
• Publication Date: 2022-03
• Subjects: 18F-PSMA PET/CT -- angiogenesis -- PET/CT -- Paget disease; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003867
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 18 F-PSMA is a promising tracer for both staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the benign pathological conditions. We report a case of 81-year-old man with a known case of prostate cancer who underwent 18 F-PSMA for restaging. 18 F-PSMA PET/CT shows intense tracer uptake in the frontal bone appearing like an "Iron Man" sign. Corresponding noncontrast CT images, pagetoid changes with thickened cortex, mixed lytic/sclerotic mottled pattern. It is important to recognize 18 F-PSMA expression in the benign nonprostatic pathologies to avoid false interpretation.