Sodium hypophosphite mediated reductive amination of carbonyl compounds with N, N-dialkylformamides. (22nd March 2023)

• Record Type: Journal Article
• Authors: Fatkulin, Artemy R.; Korochantsev, Vasily; Afanasyev, Oleg I.; Podyacheva, Evgeniya; Chusova, Olga; Muratov, Dmitry V.; Godovikova, Maria I.; Semenov, Sergei; Chusov, Denis
• Is Part Of: New journal of chemistry. Volume 47:Number 14(2023)
• Page Start: 6532
• Page End: 6535
• Publication Date: 2023-03-22
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d3nj00728f
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2 PO2 ·H2 O. The general trends and limitations of the method were explored. Abstract : Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2 PO2 ·H2 O. A set of various N, N -dimethylamines were obtained in moderate to excellent yields without chromatographic purification. The general trends and limitations of the method with different formamides as sources of dialkyl-fragments were explored.