Endometrial Cancer Surgery With or Without Concomitant Stress Urinary Incontinence Surgery. Issue 4 (9th April 2023)

• Record Type: Journal Article
• Authors: Robison, Katina; Wohlrab, Kyle; Howe, Chanelle J.; Richter, Holly E.; Sung, Vivian; Bevis, Kerri S.; Luis, Christine; McCourt, Carolyn; Lowder, Jerry; Occhino, John; Glaser, Gretchen; Lokich, Elizabeth; Dunivan, Gena; Brown, Amy; Tunitsky-Bitton, Elena; Wethington, Stephanie; Chen, Chi Chiung Grace; Rahn, David; Carlson, Matthew; Cram, Robin; Raker, Christina; Clark, Melissa A.
• Is Part Of: Obstetrics and gynecology. Volume 141:Issue 4(2023)
• Page Start: 642
• Page End: 652
• Publication Date: 2023-04-09
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/AOG.0000000000005059
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : Concomitant surgery did not result in improved quality of life compared with cancer surgery alone for patients with endometrial intraepithelial neoplasia and those with early-stage endometrial cancer with stress urinary incontinence. Abstract : OBJECTIVE: To compare quality of life (QOL) among patients with endometrial intraepithelial neoplasia or early-stage endometrial cancer and stress urinary incontinence (SUI) who chose to have concomitant surgery with cancer surgery alone. METHODS: A multicenter, prospective cohort study was conducted across eight U.S. sites. Potentially eligible patients were screened for SUI symptoms. Those who screened positive were offered referral to urogynecology and incontinence treatment, including concomitant surgery. Participants were categorized into two groups: 1) concomitant cancer and SUI surgery or 2) cancer surgery alone. The primary outcome was cancer-related QOL as measured by the FACT-En (Functional Assessment of Cancer Therapy–Endometrial) (range 0–100; higher score indicates better QOL). The FACT-En and questionnaires assessing urinary symptom–specific severity and effects were assessed before surgery and 6 weeks, 6 months, and 12 months after surgery. Adjusted median regression accounting for clustering was used to examine the relationship between SUI treatment group and FACT-En scores. RESULTS: Of 1, 322 (53.1%) patients, 702 screened positive for SUI with 532 analyzed; 110 (21%) chose concomitant cancer and SUI surgery, and 422 (79%) chose cancer surgery alone. FACT-En scores increased for both the concomitant SUI surgery and cancer surgery–only groups from the preoperative to the postoperative period. After adjustment for timepoint and preoperative covariates, the median change in FACT-En score (postoperative−preoperative) was 1.2 points higher (95% CI −1.3 to 3.6) for the concomitant SUI surgery group compared with the cancer surgery–only group across the postoperative period. Median time until surgery (22 days vs 16 days; P <.001), estimated blood loss (150 mL vs 72.5 mL; P <.001), and operative time (185.5 minutes vs 152 minutes; P <.001) were all greater for the concomitant cancer and SUI surgery group compared with the cancer-only group, respectively. CONCLUSION: Concomitant surgery did not result in improved QOL compared with cancer surgery alone for endometrial intraepithelial neoplasia and patients with early-stage endometrial cancer with SUI. However, FACT-En scores were improved in both groups.