Dual and Sequential Locked/Unlocked Photochromic Effects on FRET Controlled Singlet Oxygen Processes by Contracted/Extended Forms of Diarylethene‐Based [1]Rotaxane Nanoparticles. Issue 11 (11th December 2022)

• Record Type: Journal Article
• Authors: Khang, Trang Manh; Nhien, Pham Quoc; Cuc, Tu Thi Kim; Weng, Chang‐Ching; Wu, Chia‐Hua; Wu, Judy I.; Hue, Bui Thi Buu; Li, Yaw‐Kuen; Lin, Hong‐Cheu
• Is Part Of: Small. Volume 19:Issue 11(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-11
• Subjects: aggregation‐induced emission luminogen -- FRET -- mechanically interlocked molecule -- photochromic -- singlet oxygen generation; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202205597
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Manipulations of singlet oxygen ( 1 O2 ) generations by the integration of both aggregation‐induced emission luminogen (AIEgen) photosensitizer and photochromic moieties have diversified features in photodynamic therapy applications. Through Förster resonance energy transfer (FRET) pathway to induce red PL emissions (at 595 nm) for 1 O2 productions, [1]rotaxane containing photosensitive tetraphenylethylene (TPE) donor and photochromic diarylethene (DAE) acceptor is introduced to achieve dual and sequential locked/unlocked photoswitching effects by pH‐controlled shuttling of its contracted/extended forms. Interestingly, the UV‐enabled DAE ring closure speeds follow the reversed trend of DAE self‐constraint degree as: contracted < extended < noninterlocked forms in [1]rotaxane analogues, thus FRET processes can be adjusted in contracted/extended forms of [1]rotaxane upon UV irradiations. Accordingly, the contracted form of [1]rotaxane is FRET‐OFF locked and inert to UV exposure due to the larger bending conformation of DAE parallel (p‐)conformer, compared with its extended and noninterlocked analogues possessing switchable FRET‐OFF/ON behaviors activated by dual and sequential pH‐ and photoswitching. Owing to the advantages of 1 O2 productions tuned by multistimuli inputs (pH, UV, and blue light), an useful logic circuit for toxicity outputs of the surface modified [1]rotaxane nanoparticles (NPs) has been demonstrated to offer promising 1 O2 productions and managements based on mechanically interlocked molecules for future bioapplications. Abstract : Through Förster resonance energy transfer (FRET) to induce red PL emissions and 1 O2 productions, [1]rotaxane containing a photosensitive tetraphenylethylene donor and a photochromic diarylethene (DAE) acceptor is introduced to achieve dual and sequential locked/unlocked photoswitching effects by pH‐controlled shuttling of its contracted/extended forms upon UV irradiations by following UV‐enabled DAE ring closure speeds of contracted < extended < noninterlocked forms.