Colon Involvement in Necrotizing Pancreatitis: Incidence, Risk Factors, and Outcomes. Issue 3 (March 2022)

• Record Type: Journal Article
• Authors: Maatman, Thomas K.; Nicolas, Megan E.; Roch, Alexandra M.; Lewellen, Kyle A.; Al-Azzawi, Hayder H.; Ceppa, Eugene P.; House, Michael G.; Nakeeb, Attila; Schmidt, Christian M.; Zyromski, Nicholas J.
• Is Part Of: Annals of surgery. Volume 275:Issue 3(2022)
• Publication Date: 2022-03
• Subjects: acute necrotizing -- Clostridium difficile -- colectomy -- colitis -- ischemic -- mesenteric venous thrombosis -- pancreatitis; Surgery -- Periodicals; 617.005
• DOI: 10.1097/SLA.0000000000004149
• Languages: English
• ISSNs: 0003-4932

Abstract

Abstract : Objective: To investigate the incidence, risk factors, and outcomes of colon involvement in patients with necrotizing pancreatitis. Summary/Background Data: Necrotizing pancreatitis is characterized by a profound inflammatory response with local and systemic implications. Mesocolic involvement can compromise colonic blood supply leading to ischemic complications; however, few data exist regarding this problem. We hypothesized that the development of colon involvement in necrotizing pancreatitis (NP) negatively affects morbidity and mortality. Methods: Six hundred forty-seven NP patients treated between 2005 and 2017 were retrospectively reviewed to identify patients with colon complications, including ischemia, perforation, fistula, stricture/obstruction, and fulminant Clostridium difficile colitis. Clinical characteristics were analyzed to identify risk factors and effect of colon involvement on morbidity and mortality. Results: Colon involvement was seen in 11% (69/647) of NP patients. Ischemia was the most common pathology (n = 29) followed by perforation (n = 18), fistula (n = 12), inflammatory stricture (n = 7), and fulminant C difficile colitis (n = 3). Statistically significant risk factors for developing colon pathology include tobacco use (odds ratio (OR), 2.0; 95% confidence interval (CI), 1.2–3.4, P = 0.009), coronary artery disease (OR, 1.9; 95% CI, 1.1–3.7; P = 0.04), and respiratory failure (OR, 4.7; 95% CI, 1.1–26.3; P = 0.049). When compared with patients without colon involvement, NP patients with colon involvement had significantly increased overall morbidity (86% vs 96%, P = 0.03) and mortality (8% vs 19%, P = 0.002). Conclusion: Colon involvement in necrotizing pancreatitis is common; clinical deterioration should prompt its evaluation. Risk factors include tobacco use, coronary artery disease, and respiratory failure. Colon involvement in necrotizing pancreatitis is associated with substantial morbidity and mortality.