Rücktitelbild: Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy (Angew. Chem. 16/2023). (15th March 2023)

• Record Type: Journal Article
• Authors: Ho, Tiffany; Guidolin, Keegan; Makky, Ali; Valic, Michael; Ding, Lili; Bu, Jiachuan; Zheng, Mark; Cheng, Miffy H. Y.; Yau, Jeremy; Chen, Juan; Zheng, Gang
• Is Part Of: Angewandte Chemie. Volume 135:Number 16(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-15
• Subjects: Cancer -- EDTA -- Nanoparticles -- Photodynamic Therapy -- Porphyrin; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202303145
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract : The superior efficacy of aminopolycarboxylic acid conjugated lipid nanoparticles over standard liposomal nanoparticles is described by Juan Chen, Gang Zheng et al. in their Research Article (e202218218) . EDTA–lipid based nanoparticles fluidize the cell membrane in a detergent‐like manner and improve delivery to the cell by 25‐fold. This novel nanoparticle design feature can be deployed across lipid nanoparticles to accelerate cancer nanomedicine drug delivery.