Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator. (February 2023)

• Record Type: Journal Article
• Authors: Wang, Jieru; Gao, Ruiqin; Cao, Shiwei; Qin, Zhi; Lin, Mu; Huang, Qinggang; Yao, Zeen
• Is Part Of: Applied radiation and isotopes. Volume 192(2023)
• Publication Date: 2023-02
• Subjects: Double-column chromatography separation technique -- Separation of 68Ge -- Ga–Ni target -- SnO2-based 68Ge/68Ga generator; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2022.110599
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: A double-column chromatography separation technique was involved for isolation of 68 Ge from a bombarded Ga–Ni alloy target. About 185 MBq 68 Ge obtained was used for assembling SnO2 -based 68 Ge/ 68 Ga generator. Approximately 70% of 68 Ga in high radioactivity concentration was eluted from generator with excellent radionuclidic, radiochemical and chemical purity. 68 Ga was quite adequate for radiolabeling with DOTATATE or PSMA-617 with a high labelling efficiency of >92%. The double-column chromatography technique possessed a potential application prospect of 68 Ge/ 68 Ga production, aiding the development of 68 Ga in nuclear medicine. Highlights: A double-column chromatography separation technique was adopted to isolate 68 Ge from an irradiated Ga–Ni alloy target. A SnO2 -based 68 Ge/ 68 Ga generator has been assembled successfully. Th e 68 Ga eluates with excellent purity was labelled with DOTATATE and PSMA-617 with a high efficiency of ＞92%.