Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals. Issue 4 (19th February 2023)

• Record Type: Journal Article
• Authors: von Borstel, Anouk; Nguyen, Thi HO; Rowntree, Louise C; Ashhurst, Thomas M; Allen, Lilith F; Howson, Lauren J; Holmes, Natasha E; Smibert, Olivia C; Trubiano, Jason A; Gordon, Claire L; Cheng, Allen C; Kent, Stephen J; Rossjohn, Jamie; Kedzierska, Katherine; Davey, Martin S
• Is Part Of: Immunology and cell biology. Volume 101:Issue 4(2023)
• Page Start: 321
• Page End: 332
• Publication Date: 2023-02-19
• Subjects: COVID‐19 -- SARS‐CoV‐2 -- Vδ1 T cells -- Vδ2 T cells -- γδ T cells; Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1111/imcb.12623
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes severe coronavirus disease 2019 (COVID‐19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS‐CoV‐2, but our understanding of the cellular immune parameters that contribute to severe COVID‐19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID‐19 in unvaccinated patients with acute disease. We found that circulating CD27 neg CD45RA + CX3CR1 + Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID‐19 patients with acute disease. Moreover, higher frequencies of GzmB + Vδ2 + T cells were observed in acute COVID‐19 patients. SARS‐CoV‐2 infection did not alter the γδ T cell receptor repertoire of either Vδ1 + or Vδ2 + subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID‐19 in unvaccinated individuals. Abstract : The immune system plays a role in controlling SARS‐CoV‐2 but our understanding of the immune compartments that contribute to COVID19 disease are incomplete. In this study we show that populations of effector gamma delta T cells are associated with acute COVID‐19 in unvaccinated patients.