Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors. (April 2023)

• Record Type: Journal Article
• Authors: Bono, Federica; Fiorentini, Chiara; Mutti, Veronica; Tomasoni, Zaira; Sbrini, Giulia; Trebesova, Hanna; Marchi, Mario; Grilli, Massimo; Missale, Cristina
• Is Part Of: Pharmacological research. Volume 190(2023)
• Publication Date: 2023-04
• Subjects: nAChRs Neuronal Nicotinic Acetylcholine Receptors -- BiFC fluorescence complementation -- FCS fluorescence correlation spectroscopy -- GPCRs G protein-coupled receptors -- ER endoplasmic reticulum -- TM transmembrane helices -- ICL3 third intracellular loops -- BRET bioluminescence resonance energy transfer -- FRET fluorescence resonance energy transfer -- PLA proximity ligation assays -- BiFC bimolecular luminescence or fluorescence complementation -- PD Parkinson's Disease -- P2XR purinergic P2X receptors -- DA dopamine -- NE norepinephrine -- iPSCs pluripotent stem cells -- alpha-syn alpha-synuclein -- ACh acetylcholine -- NAc nucleus accumbens -- RLuc Renilla Luciferase -- GFP green fluorescent protein -- PI3K phosphoinositide-3-kinase–protein kinase -- p70S6K cytosolic p70 ribosomal S6 kinase -- NMDARs N-methyl-D-aspartate receptors -- GluRs Glutamate receptors -- AMPARs α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; Neuronal nicotinic receptors -- Heteromers -- Crosstalk -- Dopamine release -- Receptor-receptor interaction; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2023.106711
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of neuronal diseases including Parkinson's disease, Alzheimer's disease, epilepsy, and nicotine addiction. The influence of nAChRs on brain function depends on the activity of other neurotransmitter receptors that co-exist with nAChRs on neurons. In fact, the crosstalk between receptors is an important mechanism of neurotransmission modulation and plasticity. This may be due to converging intracellular pathways but also occurs at the membrane level, because of direct physical interactions between receptors. In this line, this review is dedicated to summarizing how nAChRs and other ionotropic and metabotropic receptors interact and the relevance of nAChRs cross-talks in modulating various neuronal processes ranging from the classical modulation of neurotransmitter release to neuron plasticity and neuroprotection. Graphical Abstract: ga1