Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis. Issue 2 (20th January 2023)

• Record Type: Journal Article
• Authors: Raffin, Jérémy; Rolland, Yves; Parini, Angelo; Lucas, Alexandre; Guyonnet, Sophie; Vellas, Bruno; de Souto Barreto, Philipe
• Other Names: Vellas Bruno investigator.; Guyonnet Sophie investigator.; Carrié Isabelle investigator.; Brigitte Lauréane investigator.; Faisant Catherine investigator.; Lala Françoise investigator.; Delrieu Julien investigator.; Villars Hélène investigator.; Combrouze Emeline investigator.; Badufle Carole investigator.; Zueras Audrey investigator.; Andrieu Sandrine investigator.; Cantet Christelle investigator.; Morin Christophe investigator.; Abellan Van Kan Gabor investigator.; Dupuy Charlotte investigator.; Rolland Yves investigator.; Caillaud Céline investigator.; Ousset Pierre‐Jean investigator.; Lala Françoise investigator.; Willis Sherry investigator.; Belleville Sylvie investigator.; Gilbert Brigitte investigator.; Fontaine Francine investigator.; Dartigues Jean‐François investigator.; Marcet Isabelle investigator.; Delva Fleur investigator.; Foubert Alexandra investigator.; Cerda Sandrine investigator.; Cuffi Marie Noëlle investigator.; Costes Corinne investigator.; Rouaud Olivier investigator.; Manckoundia Patrick investigator.; Quipourt Valérie investigator.; Marilier Sophie investigator.; Franon Evelyne investigator.; Bories Lawrence investigator.; Pader Marie‐Laure investigator.; Basset Marie‐France investigator.; Lapoujade Bruno investigator.; Faure Valérie investigator.; Li Yung Tong Michael investigator.; Malick‐Loiseau Christine investigator.; Cazaban‐Campistron Evelyne investigator.; Desclaux Françoise investigator.; Blatge Colette investigator.; Dantoine Thierry investigator.; Laubarie‐Mouret Cécile investigator.; Saulnier Isabelle investigator.; Clément Jean‐Pierre investigator.; Picat Marie‐Agnès investigator.; Bernard‐Bourzeix Laurence investigator.; Willebois Stéphanie investigator.; Désormais Iléana investigator.; Cardinaud Noëlle investigator.; Bonnefoy Marc investigator.; Livet Pierre investigator.; Rebaudet Pascale investigator.; Gédéon Claire investigator.; Burdet Catherine investigator.; Terracol Flavien investigator.; Pesce Alain investigator.; Roth Stéphanie investigator.; Chaillou Sylvie investigator.; Louchart Sandrine investigator.; Sudres Kristel investigator.; Lebrun Nicolas investigator.; Barro‐Belaygues Nadège investigator.; Touchon Jacques investigator.; Bennys Karim investigator.; Gabelle Audrey investigator.; Romano Aurélia investigator.; Touati Lynda investigator.; Marelli Cécilia investigator.; Pays Cécile investigator.; Robert Philippe investigator.; Le Duff Franck investigator.; Gervais Claire investigator.; Gonfrier Sébastien investigator.; Gasnier Yannick investigator.; Bordes Serge investigator.; Begorre Danièle investigator.; Carpuat Christian investigator.; Khales Khaled investigator.; Lefebvre Jean‐François investigator.; Misbah El Idrissi Samira investigator.; Skolil Pierre investigator.; Salles Jean‐Pierre investigator.; Dufouil Carole investigator.; Lehéricy Stéphane investigator.; Chupin Marie investigator.; Mangin Jean‐François investigator.; Bouhayia Ali investigator.; Allard Michèle investigator.; Ricolfi Frédéric investigator.; Dubois Dominique investigator.; Bonceour Martel Marie Paule investigator.; Cotton François investigator.; Bonafé Alain investigator.; Chanalet Stéphane investigator.; Hugon Françoise investigator.; Bonneville Fabrice investigator.; Cognard Christophe investigator.; Chollet François investigator.; Payoux Pierre investigator.; Voisin Thierry investigator.; Delrieu Julien investigator.; Peiffer Sophie investigator.; Hitzel Anne investigator.; Allard Michèle investigator.; Zanca Michel investigator.; Monteil Jacques investigator.; Darcourt Jacques investigator.; Molinier Laurent investigator.; Derumeaux Hélène investigator.; Costa Nadège investigator.; Perret Bertrand investigator.; Vinel Claire investigator.; Caspar‐Bauguil Sylvie investigator.; Olivier‐Abbal Pascale investigator.; Andrieu Sandrine investigator.; Cantet Christelle investigator.; Coley Nicola investigator.;
• Is Part Of: Journal of cachexia, sarcopenia and muscle. Volume 14:Issue 2(2023)
• Page Start: 771
• Page End: 780
• Publication Date: 2023-01-20
• Subjects: aging -- GDF‐15, physical activity, weight loss -- older adults; Cachexia -- Periodicals; Muscles -- Aging -- Periodicals; Muscles -- Periodicals; Cachexia; Sarcopenia; Muscles; Cachexia; Muscles; Muscles -- Aging; Periodicals; Periodicals; 616
• DOI: 10.1002/jcsm.13152
• Languages: English
• ISSNs: 2190-5991

Abstract

Abstract: Background: Late‐life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15 (GDF‐15), a stress signalling protein involved in aging, exercise and appetite control, on the association between PA and late‐life‐associated weight loss. Methods: One thousand eighty‐three healthy adults (63.8% women) aged 70 years and over who participated in the Multidomain Alzheimer Preventive Trial were included. Bodyweight (kg) and PA levels (square root of metabolic equivalent of task‐min/week) were assessed repeatedly from baseline to the 3‐year visit, whereas plasma GDF‐15 (pg/mL) was measured at the 1‐year visit. Multiple linear regressions were performed to test the association between first‐year mean PA level, 1‐year visit GDF‐15 concentration and subsequent bodyweight changes. Mediation analyses were used to investigate whether GDF‐15 mediated the association between first‐year mean PA levels and consecutive bodyweight changes. Results: Multiple regression analyses demonstrated that higher first‐year mean PA levels significantly predicted lower GDF‐15 and bodyweight at 1 year (B = −2.22; SE = 0.79; P = 0.005). In addition, higher 1‐year visit GDF‐15 levels were associated with faster subsequent bodyweight loss (Time × GDF‐15 interaction B = −0.0004; SE = 0.0001; P = 0.003). Mediation analyses confirmed that GDF‐15 mediated the association between first‐year mean PA levels and subsequent bodyweight changes (mediated effect ab = 0.0018; bootstrap SE = 0.001; P < 0.05) and revealed that mean PA had no direct effect on subsequent bodyweight changes (c′ = 0.006; SE = 0.008; P > 0.05). Conclusions: This study suggests that GDF‐15 may be one of the molecules mediating the link between PA and late‐life weight loss, but mechanistic studies are necessary to further support the present findings.