The association of preexisting severe asthma with COVID-19 outcomes. Issue 3 (17th May 2023)

• Record Type: Journal Article
• Authors: Terry, Paul D.; Heidel, R. Eric; Dhand, Rajiv
• Is Part Of: Current opinion in pulmonary medicine. Volume 29:Issue 3(2023)
• Page Start: 215
• Page End: 222
• Publication Date: 2023-05-17
• Subjects: coronavirus disease 2019 -- coronavirus disease 2019 severity -- inhaled corticosteroids -- monoclonal antibodies -- mortality -- severe acute respiratory syndrome coronavirus 2 -- severe asthma; Respiratory organs -- Diseases -- Periodicals; 616.24
• DOI: 10.1097/MCP.0000000000000954
• Languages: English
• ISSNs: 1070-5287

Abstract

Abstract : Purpose of review: Three years after the emergence of coronavirus disease 2019 (COVID-19), many studies have examined the association between asthma and COVID-related morbidity and mortality, with most showing that asthma does not increase risk. However, the U.S. Centers for Disease Control (CDC) currently suggests that patients with severe asthma may, nonetheless, be particularly vulnerable to COVID-19-related morbidity. Recent findings: With respect to poor COVID-19 outcomes, our search yielded nine studies that quantified associations with severe asthma, seven that considered use of monoclonal antibodies (mAB), and 14 that considered inhaled corticosteroids (ICS) use. mAb and ICS use have been used as measures of severe asthma in several studies. Severe asthma was significantly associated with poor COVID-19 outcomes. The results for mAb and ICS were mixed. Summary: An increased risk of poor COVID-19 outcomes in patients with severe asthma is possible. However, these studies remain sparse and suffer from several methodological limitations that hinder their interpretation. Additional evidence is needed to provide clear, cogent guidance for health agencies seeking to inform patients with asthma about potential risks due to COVID-19.