Non-stoichiometric carbamazepine cocrystal hydrates of 3, 4-/3, 5-dihydroxybenzoic acids: coformer–water exchange. Issue 26 (15th March 2023)

• Record Type: Journal Article
• Authors: Rajbongshi, Trishna; Sarmah, Kashyap Kumar; Das, Susobhan; Deka, Poonam; Saha, Arijit; Saha, Binoy K.; Puschmann, Horst; Reddy, C. Malla; Thakuria, Ranjit
• Is Part Of: Chemical communications. Volume 59:Issue 26(2023)
• Page Start: 3902
• Page End: 3905
• Publication Date: 2023-03-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06860e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A unique set of carbamazepine (CBZ) non-stoichiometric cocrystal hydrates with 34/35DHBA have been synthesized which are facilitated by their isostructural nature with the CBZ dihydrate, resulting in coformer–water exchange (molecular alloy). Abstract : The cocrystallisation of carbamazepine (CBZ) with 3, 4-/3, 5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ–DHBA cocrystals with the amount of coformer present.