Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole. (16th March 2023)

• Record Type: Journal Article
• Authors: Hall, Victoria G; Tang, Kenny; Kumar, Deepali; Rotstein, Coleman; Chow, Signy; Chan, Steven M; Husain, Shahid; Hosseini-Moghaddam, Seyed M
• Is Part Of: Open forum infectious diseases. Volume 10:Number 3(2023)
• Publication Date: 2023-03-16
• Subjects: breakthrough -- invasive fungal infection -- venetoclax -- voriconazole; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofad134
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus those who did not. Subtherapeutic voriconazole levels and a triazole exposure history may contribute to breakthrough invasive fungal infection.