Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds. Issue 9 (22nd January 2023)

• Record Type: Journal Article
• Authors: Koushik, Tejas M.; Miller, Catherine M.; Antunes, Elsa
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 9(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-22
• Subjects: biomaterials -- bone tissue engineering -- hierarchical structures; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202766
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, and the understanding of bone healing pathways have opened new avenues of research. The dual responsibility of BTE scaffolds in providing load‐bearing capability and interaction with the local extracellular matrix to promote bone healing is a challenge in synthetic scaffolds. This article describes the usage and processing of multi‐materials and hierarchical structures to mimic the structure of natural bone tissues to function as bioactive and load‐bearing synthetic scaffolds. The first part of this literature review describes the physiology of bone healing responses and the interactions at different stages of bone repair. The following section reviews the available literature on biomaterials used for BTE scaffolds followed by some multi‐material approaches. The next section discusses the impact of the scaffold's structural features on bone healing and the necessity of a hierarchical distribution in the scaffold structure. Finally, the last section of this review highlights the emerging trends in BTE scaffold developments that can inspire new tissue engineering strategies and truly develop the next generation of synthetic scaffolds. Abstract : The dual responsibility of bone tissue engineering (BTE) scaffolds in providing load‐bearing capability and interaction with the host cells to promote bone healing is a challenge. Describing the function of multi‐materials and scaffold features during this bone healing process is the core idea of this article. Understanding the bifunctionality of BTE scaffolds can promote the development of the next generation of synthetic scaffolds.