Internal dosimetry of 64Cu-DOX-loaded microcapsules by Monte Carlo method. (June 2023)

• Record Type: Journal Article
• Authors: Heidari, Samira; Sadeghi, Mahdi; Akhlaghi, Mehdi; Beiki, Davood; Yazdi, Saeideh Izadi
• Is Part Of: Applied radiation and isotopes. Volume 196(2023)
• Publication Date: 2023-06
• Subjects: Internal dosimetry -- 64Cu -- Doxorubicin -- 64Cu-DOX microcapsules -- MCNP -- MIRD; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2023.110788
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Some of the issues regarding introducing new radiocompounds in nuclear medicine are the distribution patterns, delivered dose to different organs, diagnostic abilities and side effects. In this study, in order to assess the biodistribution of 64 Cu-DOX-loaded microcapsules, rats were IV-injected with the microcapsules, and 1, 4, 14, and 24 h later, the activities of the targeted organs were measured (%ID/g). The accumulated activities were achieved by %ID/g curves, and S-factors were obtained by MCNP outputs. The MIRD formulation and Monte Carlo method were used to determine the absorbed dose in the target organs. The biodistribution data and PET-CT images showed that the lungs were where the majority of activity was seen. According to MIRD and MCNP, the maximum dose delivered in the lungs was 5.79E+01 mGy/MBq and 4.70E+01 mGy/MBq, respectively. Also, the effective dose was 1.2E+01 for MIRD and 8.31E+00 mSv/MBq for MCNP. These results indicate that 64 Cu-DOX microcapsules can be considered a new radiocompound in pulmonary imaging, and MCNP simulation can be a reliable method for internal dosimetry. Highlights: Evaluate the biodistribution of 64 Cu-DOX-loaded microcapsules in which 64 Cu-DOX-loaded microcapsules were injected to rats. The absorbed dose in the target organs was obtained by MIRD phantom and Monte Carlo method. Based on the biodistribution data and PET-CT images, the maximum activity was demonstrated in the lungs.