Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis. (March 2023)

• Record Type: Journal Article
• Authors: Nemanich, Samuel T.; Lench, Daniel H.; Sutter, Ellen N.; Kowalski, Jesse L.; Francis, Sunday M.; Meekins, Gregg D.; Krach, Linda E.; Feyma, Tim; Gillick, Bernadette T.
• Is Part Of: European journal of paediatric neurology. Volume 43(2023)
• Page Start: 27
• Page End: 35
• Publication Date: 2023-03
• Subjects: Transcranial direct current stimulation -- Perinatal stroke -- Hemiparesis -- Motor evoked potential -- Brain excitability; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2023.01.013
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Children with hemiparesis (CWH) due to stroke early in life face lifelong impairments in motor function. Transcranial direct current stimulation (tDCS) may be a safe and feasible adjuvant therapy to augment rehabilitation. Given the variability in outcomes following tDCS, tailored protocols of tDCS are required. We evaluated the safety, feasibility, and preliminary effects of a single session of targeted anodal tDCS based on individual corticospinal tract organization on corticospinal excitability. Fourteen CWH (age = 13.8 ± 3.63) were stratified into two corticospinal organization subgroups based on transcranial magnetic stimulation (TMS)-confirmed motor evoked potentials (MEP): ipsilesional MEP presence (MEPIL +) or absence (MEPIL −). Subgroups were randomized to real anodal or sham tDCS (1.5 mA, 20 min) applied to the ipsilesional (MEPIL + group) or contralesional (MEPIL − group) hemisphere combined with hand training. Safety was assessed with questionnaires and motor function evaluation, and corticospinal excitability was assessed at baseline and every 15 min for 1 h after tDCS. No serious adverse events occurred and anticipated minor side effects were reported and were self-limiting. Six of 14 participants had consistent ipsilesional MEPs (MEPIL + group). Paretic hand MEP amplitude increased in 5/8 participants who received real anodal tDCS to either the ipsilesional or contralesional hemisphere (+80% change). Application of tDCS based on individual corticospinal organization was safe and feasible with expected effects on excitability, indicating the potential for tailored tDCS protocols for CWH. Additional research involving expanded experimental designs is needed to confirm these effects and to determine if this approach can be translated into a clinically relevant intervention. Graphical abstract: Image 1 Highlights: tDCS was applied based on corticospinal organization patterns. Individualized tDCS is safe for children with hemiparesis due to stroke. A single application of anodal tDCS may increase corticospinal excitability. Similar tDCS protocols could be used for children with varied brain plasticity.