Impact of early nutrition route in patients receiving extracorporeal membrane oxygenation: A retrospective cohort study. Issue 3 (22nd July 2021)

• Record Type: Journal Article
• Authors: Brisard, Laurent; Bailly, Arthur; Le Thuaut, Aurélie; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Roussel, Jean‐Christian; Senage, Thomas; Rozec, Bertrand
• Is Part Of: JPEN, Journal of parenteral and enteral nutrition. Volume 46:Issue 3(2022)
• Page Start: 526
• Page End: 537
• Publication Date: 2021-07-22
• Subjects: cardiac surgery -- critical care -- critical illness -- digestive complications -- enteral nutrition -- energy intake -- extracorporeal membrane oxygenation -- nutrition support; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; 615.85484
• DOI: 10.1002/jpen.2209
• Languages: English
• ISSNs: 0148-6071

Abstract

Abstract: Background: Early nutrition management in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. Despite its potentially beneficial effect, enteral nutrition (EN) could be associated with gastrointestinal (GI) complications. Total daily energy requirements remain difficult to achieve with ECMO support. Analysis of nutrition practices could improve nutrition management of this particular population. Methods: A monocentric retrospective study of patients requiring ECMO in a cardiac surgery intensive care unit (ICU) between 2010 and 2014 with follow‐up ≥6 days. Nutrition support was monitored daily until ECMO weaning. We compared patients exposed (EN group, n = 49) and unexposed (No EN group (NEN), n = 63) with EN, as well as the energy and protein intakes within 4 days after initiation of ECMO. Vital status and nosocomial infections were followed up until ICU discharge. Primary outcome was the incidence of GI intolerance and risk‐factor identification. Secondary outcomes included impact of nutrition inadequacy and clinical outcome. Results: A total 112 patients were analyzed, representing 969 nutrition days. Median ratio of energy and protein prescribed/required daily was 81% (58–113) and 56% (36–86), respectively. GI intolerance was experienced by 53% (26 of 49) of patients in the EN group and was only associated with ECMO duration (odds ratio, 1.14: 95% CI, 1.00–1.31; P = .05). Low‐energy and protein days were not associated with clinical outcomes such as nosocomial infections. Conclusion: EN is associated with almost 50% GI intolerance without clinical benefit for patients receiving ECMO. Adequacy in energy and protein amounts did not affect clinical outcome.