Fabrication of Smart Tantalum Carbide MXene Quantum Dots with Intrinsic Immunomodulatory Properties for Treatment of Allograft Vasculopathy. (8th September 2021)

• Record Type: Journal Article
• Authors: Rafieerad, Alireza; Yan, Weiang; Alagarsamy, Keshav Narayan; Srivastava, Abhay; Sareen, Niketa; Arora, Rakesh C.; Dhingra, Sanjiv
• Is Part Of: Advanced functional materials. Volume 31:Number 46(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-08
• Subjects: allograft vasculopathy -- bioactive material -- hydrofluoric acid‐free synthesis -- in vivo immunomodulation -- Ta 4C 3Tx MXene quantum dots; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202106786
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: MXene nanomaterials have sparked significant interest among interdisciplinary researchers to tackle today's medical challenges. In particular, colloidal MXene quantum dots (MQDs) offer the high specific surface area and compositional flexibility of MXene while providing improvements to aqueous stability and material–cell interactions. The current study for the first time reports the development and application of immunoengineered tantalum‐carbide (Ta4 C3 T x ) MQDs for in vivo treatment of transplant vasculopathy. This report comes at a critical juncture in the field as poor long‐term safety of other MXene compositions challenge the eventual clinical translatability of these materials. Using rational design and synthesis strategies, the Ta4 C3 T x MQDs leverage the intrinsic anti‐inflammatory and antiapoptotic properties of tantalum to provide a novel nanoplatform for biomedical engineering. In particular, these MQDs are synthesized with high efficiency and purity using a facile hydrofluoric acid‐free protocol and are enriched with different bioactive functional groups and stable surface TaO2 and Ta2 O5 . Furthermore, MQDs are spontaneously uptaken into antigen‐presenting endothelial cells and alter surface receptor expression to reduce their activation of allogeneic T‐lymphocytes. Finally, when applied in vivo, Ta4 C3 T x MQDs ameliorate the cellular and structural changes of early allograft vasculopathy. These findings highlight the robust potential of tailored Ta4 C3 T x MQDs for future applications in medicine. Abstract : The development and application of new immunoengineered tantalum‐carbide (Ta4 C3 T x ) MXene quantum dots (MQDs) for the treatment of transplant vasculopathy are reported. Using rational design and novel synthesis strategies, these MQDs possess intrinsic anti‐inflammatory properties. These findings highlight the robust potential of smart Ta4 C3 T x MQDs for future applications in biomedical engineering and nanomedicine.