Biomimetic Tissue‐Engineered Bone Substitutes for Maxillofacial and Craniofacial Repair: The Potential of Cell Sheet Technologies. Issue 6 (27th December 2017)

• Record Type: Journal Article
• Authors: Kawecki, Fabien; Clafshenkel, William P.; Fortin, Michel; Auger, François A.; Fradette, Julie
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 6(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-12-27
• Subjects: bone substitutes -- cell sheet -- prevascularization -- stem cells -- tissue engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201700919
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Maxillofacial defects are complex lesions stemming from various etiologies: accidental, congenital, pathological, or surgical. A bone graft may be required when the normal regenerative capacity of the bone is exceeded or insufficient. Surgeons have many options available for bone grafting including the "gold standard" autologous bone graft. However, this approach is not without drawbacks such as the morbidity associated with harvesting bone from a donor site, pain, infection, or a poor quantity and quality of bone in some patient populations. This review discusses the various bone graft substitutes used for maxillofacial and craniofacial repair: allografts, xenografts, synthetic biomaterials, and tissue‐engineered substitutes. A brief overview of bone tissue engineering evolution including the use of mesenchymal stem cells is exposed, highlighting the first clinical applications of adipose‐derived stem/stromal cells in craniofacial reconstruction. The importance of prevascularization strategies for bone tissue engineering is also discussed, with an emphasis on recent work describing substitutes produced using cell sheet‐based technologies, including the use of thermo‐responsive plates and the self‐assembly approach of tissue engineering. Indeed, considering their entirely cell‐based design, these natural bone‐like substitutes have the potential to closely mimic the osteogenicity, osteoconductivity, osteoinduction, and osseointegration properties of autogenous bone for maxillofacial and craniofacial reconstruction. Abstract : Many options are available for the management of craniomaxillofacial repair. In this Review, multiple types of bone graft materials with an emphasis on recent studies describing substitutes produced using cell sheet‐based technologies are discussed. Indeed, considering their entirely cell‐based design, these natural substitutes have the potential to closely mimic essential properties of autogenous bone for craniomaxillofacial reconstruction.