IL‐28β gene polymorphism determines virological response to PEGylated interferon therapy in hepatitis C virus genotype 4 Egyptian patients. Issue 5 (18th November 2018)

• Record Type: Journal Article
• Authors: El‐Khazragy, Nashwa; El Sayed, Naglaa; Salem, Ahmed M.; Hassan, Nahla S.; Abdelmoeaz, Amal Tohamy; Maher, Amany M.; Mansy, Azza El‐Sayed
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 5(2019)
• Page Start: 8154
• Page End: 8159
• Publication Date: 2018-11-18
• Subjects: IL28β gene polymorphism -- PEGylated interferon/ribavirin -- rs12979860 -- sustained virological response; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28096
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Background: PEGylated interferon (PEG‐IFN) in combination with ribavirin is the gold standard for chronic hepatitis C virus (HCV). The majority of patients received PEG‐IFN/ribavirin achieve a sustained viral response (SVR), but few cases failed to respond. It was evident that host genetic factors determine the treatment‐induced viral clearance as well as spontaneous response. In the current study, the rs12979860 polymorphism of IL28β gene was analyzed and its association with the virological response to PEG‐IFN treatment was determined. Methods: One hundred and fifty Egyptian patients with HCV genotype 4 treated with PEG‐IFN/ribavirin were assessed at 12 and 24 weeks of therapy, the rs12979860 genotype was determined using TaqMan‐based quantitative polymerase chain reaction. Results: Although the CC genotype was the most frequent (58%), the higher SVR was achieved for patients with favorable CC genotype (93%) in contrast to CT and TT genotypes. Conclusion: we conclude that IL28B polymorphism is highly associated with SVR to therapy in the Egyptian population infected with HCV genotype 4 and patients who carry CC genotype have a higher chance of SVR. Abstract : Although combined PEGylated interferon/ribavirin is a gold standard antiviral therapy for hepatitis C virus (HCV)‐4, few cases failed to respond which seems to be related to host genetic factors. Therefore, we investigate the prediction value of rs12979860 polymorphism in Egyptian patients. Our results revealed that IL28B polymorphism is highly associated with sustained viral response (SVR) to therapy in the Egyptian population infected with HCV genotype 4 and patients who carry CC genotype have a higher chance of SVR.