Palladium‐Based Metallic Glass with High Thrombogenic Resistance for Blood‐Contacting Medical Devices. (17th October 2021)

• Record Type: Journal Article
• Authors: Cihova, Martina; Müller, Eike; Chandorkar, Yashoda; Thorwarth, Kerstin; Fortunato, Giuseppino; Maniura‐Weber, Katharina; Löffler, Jörg F.; Rottmar, Markus
• Is Part Of: Advanced functional materials. Volume 32:Number 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-17
• Subjects: blood‐contacting devices -- coagulation -- hemocompatibility -- metallic glass -- palladium -- platelet activation -- thrombogenicity; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202108256
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Advancements in the design of mechanical blood circulatory devices have greatly improved patient survival rates, but currently employed metals still provoke a thrombosis response upon contact with blood, with potential life‐threatening consequences. While coating strategies have been developed to address this limitation, they possess inherent drawbacks such as susceptibility to crack formation and delamination. Herein, an amorphous metal based on palladium (Pd) is scrutinized and reveals substantial thrombogenic resistance compared to a state‐of‐the‐art titanium alloy. In vitro assessment with human whole blood shows that the Pd glass provokes reduced platelet activation (lower expression of CD62P, CD41/CD61) and greatly retarded fibrin formation, but pronounced platelet spreading therewith challenging the dogma that platelet spreading equals activation. Mechanistic analysis of the early biomaterial–blood interactions reveals that conformational changes of adhered fibrinogen, and modified αIIb β3 integrin expression and distribution across adhered platelets, underlay the superior performance of Pd glass. The study is accompanied by structural and thermophysical bulk investigations and physicochemical surface characterization to link the materials properties with the observed blood response. The results reveal a remarkable potential of Pd‐based glass as direct blood‐contacting bulk material without the need for coating. Abstract : Metallic biomaterials are inevitable for the functioning of mechanical blood pumps but induce a thrombosis response upon contact with blood that can be life‐threatening. This work showcases an amorphous metal based on noble palladium that largely outperforms a state‐of‐the‐art titanium alloy. Through combination of material and biological investigations, this work unravels mechanistic insights underlying the low thrombogenicity of Pd‐based metallic glass.