Low expression of ENC1 predicts a favorable prognosis in patients with ovarian cancer. Issue 1 (20th August 2018)

• Record Type: Journal Article
• Authors: Fan, Shaohua; Wang, Yanyan; Sheng, Ning; Xie, Ying; Lu, Jun; Zhang, Zifeng; Shan, Qun; Wu, Dongmei; Sun, Chunhui; Li, Mengqiu; Hu, Bin; Zheng, Yuanlin
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 1(2019)
• Page Start: 861
• Page End: 871
• Publication Date: 2018-08-20
• Subjects: ectodermal‐neural cortex 1 -- ovarian cancer -- prognosis; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.27447
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Ectodermal‐neural cortex 1 (ENC1) belongs to a member of the kelch family of genes. It is an actin‐binding protein and plays a pivotal role in neuronal and adipocyte differentiation. Here, we found that lower expression of ENC1 in the ovarian cancer patients was associated with favorable prognosis. In addition, ENC1 was heterogeneously expressed in various ovarian cancer cells. The messenger RNA and protein expression levels of ENC1 in HO‐8910PM and NIH:OVCAR‐3 cells were obviously higher than that in the other types of ovarian cancer cells. Knockdown of ENC1 in HO‐8910PM or NIH:OVCAR‐3 cells could significantly increase the reactive oxygen species levels, resulting in inhibition of in vitro proliferation, migration, and invasion. Our findings suggest that decreasing expression of ENC1 may be a new approach that can be used for ovarian cancer treatment. Abstract : We demonstrated that knockdown of ENC1 can significantly inhibit ovarian cancer cell proliferation, migration and invasion. The analysis of ENC1 expression in clinical specimens showed that low expression of ENC1 was associated with favorable prognosis in ovarian cancer patients