Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural‐like cells. Issue 8 (5th January 2019)

• Record Type: Journal Article
• Authors: Esmaeili, Elaheh; Soleimani, Masoud; Ghiass, Mohammad Adel; Hatamie, Shadie; Vakilian, Saeed; Zomorrod, Mahsa Soufi; Sadeghzadeh, Negar; Vossoughi, Manouchehr; Hosseinzadeh, Simzar
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 8(2019:Aug.)
• Page Start: 13617
• Page End: 13628
• Publication Date: 2019-01-05
• Subjects: electrospinning -- magnetoelectric -- mesenchymal stem cells -- neural differentiation -- scaffold; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28040
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe2 O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators. Abstract : The achievements of this study can provide a new way to fabricate magnetoelectric scaffolds of high performance to be used for neural cell differentiation with no need to chemical differentiation media and consequently avoiding their unwanted effects.