The alternative approach: genomic classifiers for prognostication in interstitial lung disease. Issue 4 (3rd April 2023)

• Record Type: Journal Article
• Authors: Goobie, Gillian C.; Guler, Sabina A.
• Is Part Of: European respiratory journal. Volume 61:Issue 4(2023)
• Publication Date: 2023-04-03
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00033-2023
• Languages: English
• ISSNs: 0903-1936

Abstract

Interstitial lung disease (ILD) reflects a large group of entities characterised by pulmonary parenchymal inflammation and fibrosis, with many patients suffering from functional limitation, progressive symptoms and accelerated mortality [1]. Idiopathic pulmonary fibrosis (IPF), which is characterised by a usual interstitial pneumonia (UIP) pattern on imaging and histology, is the most common and deadly form of ILD [2, 3]. Prognosis and treatment approaches differ between ILD subtypes, making an accurate diagnosis crucial; however, this can be challenging due to overlapping clinical and morphological presentations of some ILDs. The potential of genomic classifiers for ILD prognostication has not been exhausted yet http://bit.ly/3ZMMdjx