New strategy of bone marrow mesenchymal stem cells against oxidative stress injury via Nrf2 pathway: oxidative stress preconditioning. Issue 12 (26th July 2019)

• Record Type: Journal Article
• Authors: Zhang, Fei; Peng, Wuxun; Zhang, Jian; Dong, Wentao; Yuan, Dajiang; Zheng, Yinggang; Wang, Zhenwen
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 12(2019)
• Page Start: 19902
• Page End: 19914
• Publication Date: 2019-07-26
• Subjects: bone marrow mesenchymal stem cells -- oxidative stress -- preconditioning -- reactive oxygen species; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.29298
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Clinically, bone marrow mesenchymal stem cells (BMSCs) have been used in treatment of many diseases, but the local oxidative stress (OS) of lesion severely limits the survival of BMSCs, which reduces the efficacy of BMSCs transplantation. Therefore, enhancing the anti‐OS stress ability of BMSCs is a key breakthrough point. Preconditioning is a common protective mechanism for cells or body. Here, the aim of this study was to investigate the effects of OS preconditioning on the anti‐OS ability of BMSCs and its mechanism. Fortunately, OS preconditioning can increase the expression of superoxide dismutase, catalase, NQO1, and heme oxygenase 1 through the nuclear factor erythroid 2‐related factor 2 pathway, thereby decreased the intracellular reactive oxygen species (ROS) levels, relieved the damage of ROS to mitochondria, DNA and cell membrane, enhanced the anti‐OS ability of BMSCs, and promoted the survival of BMSCs under OS. Abstract : Oxidative stress (OS) preconditioning can enhance the anti‐OS ability of bone marrow mesenchymal stem cells (BMSCs), and promote the survival of BMSCs under OS microenvironment. Which mechanism is that OS preconditioning can increase the expression of superoxide dismutase, catalase, NQO1, and heme oxygenase 1 via the nuclear factor erythroid 2‐related factor 2 pathway