Characteristics of individuals with alpha-1 antitrypsin deficiency from Northern and Southern European countries: EARCO international registry. Issue 3 (30th March 2023)

• Record Type: Journal Article
• Authors: Miravitlles, Marc; Turner, Alice M.; Torres-Duran, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos, José Luis; Chlumsky, Jan; Guimaraes, Catarina; Rodríguez-Hermosa, Juan Luis; Corsico, Angelo; Martinez-González, Cristina; Hernández-Pérez, José María; Bustamante, Ana; Parr, David G.; Casas-Maldonado, Francisco; Hecimovic, Ana; Janssens, Wim; Lara, Beatriz; Barrecheguren, Miriam; González, Cruz; Stolk, Jan; Esquinas, Cristina; Clarenbach, Christian F.
• Is Part Of: European respiratory journal. Volume 61:Issue 3(2023)
• Publication Date: 2023-03-30
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01949-2022
• Languages: English
• ISSNs: 0903-1936

Abstract

The EARCO registry contains information on >1000 patients with AATD from 15 countries. The demographic characteristics and the disease characteristics are not significantly different in individuals from Northern or Southern European countries. https://bit.ly/3EdGGcC Alpha-1 antitrypsin deficiency (AATD) is characterised by low serum levels of alpha-1 antitrypsin (AAT) and predisposes to the development of pulmonary emphysema and liver disease [1]. This deficiency is considered a rare condition and its prevalence ranges from one in 2400 to one in 6000 individuals in Western European countries [2]. Due to its low prevalence, large observational prospective registries are needed to collect information about the clinical characteristics and prognosis of the individuals affected.