Frontispiece: Rational design of allosteric switchable catalysts (EXP2 2/2022). Issue 2 (18th April 2022)

• Record Type: Journal Article
• Authors: Pan, Tiezheng; Wang, Yaling; Xue, Xue; Zhang, Chunqiu
• Is Part Of: Exploration. Volume 2:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-18
• Subjects: Ultrastructure (Biology); Periodicals; 620.5
• DOI: 10.1002/EXP.20210340
• Languages: English
• ISSNs: 2766-8509

Abstract

Abstract : Toolbox of allosteric catalysts Allosteric regulation that controls the activities of natural enzymes motivates the exploration of expanded toolbox of switchable catalysts for chemical biology research. This review presents prospects of how allosteric scaffolds, ranging from single molecules to self‐assemblies, could be designed into artificial switchable catalysts. The strategy of conformation‐catalysis synergistics provides great inspirations and opportunities for fundamental research and biomedical applications.