Inside Back Cover: Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells (Angew. Chem. Int. Ed. 20/2022). Issue 20 (8th April 2022)

• Record Type: Journal Article
• Authors: Desai, Prachi; Rimal, Rahul; Florea, Alexandru; Gumerov, Rustam A.; Santi, Marta; Sorokina, Anastasia S.; Sahnoun, Sabri E. M.; Fischer, Thorsten; Mottaghy, Felix M.; Morgenroth, Agnieszka; Mourran, Ahmed; Potemkin, Igor I.; Möller, Martin; Singh, Smriti
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 20(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-08
• Subjects: Biodistribution -- Elasticity -- Nanogels -- Phagocytosis -- Radiolabeling; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202204930
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Mechanical properties of nanogels influence their cellular fate. Inspired by the natural ability of the cells to sense stiffness, Smriti Singh et al. in their Research Article (e202116653) developed highly hydrophilic soft nanogels and show that the passive engulfment of the soft nanogels by the immune cells was drastically reduced compared to the stiffer counterpart. The delayed uptake resulted in an enhanced circulation time of the nanogels, an important criterion for drug delivery applications.