"Topical nephropathy" and "tropical extramembranous glomerulonephritis" of unknown aetiology in Senegal. Issue 5957 (8th March 1975)

• Record Type: Journal Article
• Authors: Morel-Maroger, L; Saimot, A G; Sloper, J C; Woodrow, D F; Adam, C; Niang, I; Payet, M
• Is Part Of: BMJ. Volume 1:Issue 5957(1975)
• Page Start: 541
• Page End: 546
• Publication Date: 1975-03-08
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.5957.541
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : A study of renal biopsy specimens obtained in Senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16 cases). The latter, though lacking the diffuse glomerular deposits of immunoglobulin described in quartan malarial nephropathy (Q.M.N.), showed a curious progressive and segmental glomerulosclerosis, characterized by a "flaking" or fibrillary splitting of the glomerular capillary wall, seen in Q.M.N. Serological evidence of malaria was lacking in a third of the childhood cases.