Homeostatic control of redox status and health. Issue 1 (6th July 2021)

• Record Type: Journal Article
• Authors: Sies, Helmut; Ursini, Fulvio
• Other Names: Ozer Nesrin Kartal guestEditor.; Vina Jose guestEditor.; Olaso Gloria guestEditor.; Sozen Erdi guestEditor.
• Is Part Of: IUBMB life. Volume 74:Issue 1(2022)
• Page Start: 24
• Page End: 28
• Publication Date: 2021-07-06
• Subjects: COVID‐19 -- hormesis -- oxidative eustress -- parahormesis -- redox biology -- steady state; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2519
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: Research on oxidants and electrophiles has shifted from focusing on damage to biomolecules to the more fine‐grained physiological arena. Redox transitions as excursions from a steady‐state redox set point are continually ongoing in maintenance of redox balance. Current excitement on these topics results from the fact that recent research provided mechanistic insight, which gives rise to more concrete and differentiated questions. This Commentary focuses on redox eustress and the feedback restoration of steady state as concepts in active maintenance of physiological health, with brief discussion of redox stress response to viral infection, exemplified by COVID‐19.