Structure of MeuNaTxα‐1 toxin from scorpion venom highlights the importance of the nest motif. Issue 8 (24th March 2021)
- Record Type:
- Journal Article
- Title:
- Structure of MeuNaTxα‐1 toxin from scorpion venom highlights the importance of the nest motif. Issue 8 (24th March 2021)
- Main Title:
- Structure of MeuNaTxα‐1 toxin from scorpion venom highlights the importance of the nest motif
- Authors:
- Mineev, Konstantin S.
Kuzmenkov, Alexey I.
Arseniev, Alexander S.
Vassilevski, Alexander A. - Abstract:
- Abstract: Old world scorpions produce an abundance of toxins called α‐NaTx, which interfere with the fast inactivation of voltage‐gated sodium channels. Their selectivity to channels of mammals or insects depends on a part of toxin named the specificity module. We report here the spatial structure of a major and broadly active toxin MeuNaTxα‐1 from the venom of Mesobuthus eupeus . Notably, its specificity module is markedly different from other α‐NaTx with known 3D structure. Close inspection shows that its conformation is a result of an interplay between protein motifs such as the nest and niche, which eventually shape α‐NaTx structural diversity.
- Is Part Of:
- Proteins. Volume 89:Issue 8(2021)
- Journal:
- Proteins
- Issue:
- Volume 89:Issue 8(2021)
- Issue Display:
- Volume 89, Issue 8 (2021)
- Year:
- 2021
- Volume:
- 89
- Issue:
- 8
- Issue Sort Value:
- 2021-0089-0008-0000
- Page Start:
- 1055
- Page End:
- 1060
- Publication Date:
- 2021-03-24
- Subjects:
- ion channel -- neurotoxin -- protein motif -- voltage‐gated sodium channel
Proteins -- Periodicals
Proteins -- Periodicals
572.6 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/prot.26074 ↗
- Languages:
- English
- ISSNs:
- 0887-3585
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6936.164000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26745.xml