A "Bridge‐Building" Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization (Adv. Mater. 42/2021). Issue 42 (19th October 2021)

• Record Type: Journal Article
• Authors: Mu, Ruoyu; Zhang, Yuhan; Yan, Lingli; Liao, Zhencheng; Yang, Yushun; Su, Huanxing; Dong, Lei; Wang, Chunming
• Is Part Of: Advanced materials. Volume 33:Issue 42(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-19
• Subjects: angiogenesis -- blood vessels -- carbohydrates -- cell adhesion -- natural biomaterials; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202170334
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In Situ Endothelialization In article number 2103490, Lei Dong, Chunming Wang, and co‐workers describe how fungal sugars in bioscaffold design are mimicked to support vascular growth. When microbes invade human tissue, their surface carbo hydrates bridge the endothelium for further transmigration. Glucomannans are chemically modified and electrospun into a fibrous scaffold, which recruits galectins to bridge endothelial cells with the scaffold. This helps to recover blood perfusion in a murine ischemic model.