Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho‐associated protein kinase 1. Issue 5 (26th November 2018)

• Record Type: Journal Article
• Authors: Wan, Xiaodong; Xiang, Jun; Zhang, Qimin; Bian, Cuidong
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 5(2019)
• Page Start: 8195
• Page End: 8200
• Publication Date: 2018-11-26
• Subjects: cancer cell -- long noncoding RNAs POU3F3 -- proliferation -- prostate carcinoma -- ROCK1; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28101
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Long noncoding RNAs (lncRNAs) POU3F3 is overexpressed in esophageal squamous‐cell carcinomas, while its role in other human cancers is unclear. In this study we found that POU3F3 and rho‐associated protein kinase 1 (ROCK1) were both increased in tumor tissues than in adjacent healthy tissues of patients with prostate carcinoma. Expression levels of POU3F3 increased with increase in the diameter of tumor but were not significantly affected by lymph node metastasis or distant metastasis. Expression levels of POU3F3 and ROCK1 were positive correlated in tumor tissues but not in adjacent healthy tissues. POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effect of POU3F3 overexpression on cancer cell proliferation. POU3F3 overexpression led to ROCK1 overexpression in prostate carcinoma cells, while ROCK1 overexpression did not significantly affect POU3F3 expression. Therefore, lncRNA POU3F3 may promote cancer cell proliferation in prostate carcinoma by upregulating ROCK1. Abstract : Long noncoding RNAs (lncRNAs) POU3F3 and ROCK1 were both overexpressed in prostate carcinoma. LncRNA POU3F3 may promote cancer cell proliferation in prostate carcinoma by upregulating ROCK1.