3D printing of PLGA scaffolds for tissue engineering. Issue 1 (29th August 2016)

• Record Type: Journal Article
• Authors: Mironov, Anton V.; Grigoryev, Aleksey M.; Krotova, Larisa I.; Skaletsky, Nikolaj N.; Popov, Vladimir K.; Sevastianov, Viktor I.
• Is Part Of: Journal of biomedical materials research. Volume 105:Issue 1(2017)
• Page Start: 104
• Page End: 109
• Publication Date: 2016-08-29
• Subjects: bioresorbable polymeric scaffolds -- tissue engineering -- 3D printing -- polylactic‐co‐glycolic acids; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35871
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: We proposed a novel method of generation of bioresorbable polymeric scaffolds with specified architectonics for tissue engineering using extrusion three‐dimensional (3D) printing with solutions of polylactoglycolide in tetraglycol with their subsequent solidifying in aqueous medium. On the basis of 3D computer models, we obtained the matrix structures with interconnected system of pores ranging in size from 0.5 to 500 µm. The results of in vitro studies using cultures of line NIH 3Т3 mouse fibroblasts, floating islet cultures of newborn rabbit pancreas, and mesenchymal stem cells of human adipose tissue demonstrated the absence of cytotoxicity and good adhesive properties of scaffolds in regard to the cell cultures chosen. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 104–109, 2017.