Prognostic factors of budesonide therapy for the management of Crohn's disease: A meta‐analysis. Issue 6 (16th December 2018)

• Record Type: Journal Article
• Authors: Li, Yajun; Meng, Xiangwei; Duan, Xiumei; Tang, Tongyu; He, Chuan; Li, Yuqin
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 6(2019)
• Page Start: 10273
• Page End: 10280
• Publication Date: 2018-12-16
• Subjects: activity index -- budesonide -- Crohn's disease -- glucocorticoids -- prognosis; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28310
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Background: This study aimed to identify factors that affect the prognosis of budesonide therapy for Crohn's disease patients. Method: Change in Crohn's disease activity index (CDAI) scores at latest follow‐up after budesonide therapy reported by individual studies were pooled to gain overall effect size under random effects model and then metaregression analyses were performed to identify factors affecting the change in CDAI scores after budesonide treatment. Results: Fifteen studies (1875 patients; age, 35.6 years [95% confidence interval (CI): 34.1, 37.0]; 41.66% [95% CI: 37.44, 45.88] males; 33.3% [95% CI: 24.3, 42.3] smokers; weight, 64.7 kg [95% CI: 62.71 66.6] and height, 168 cm [95% CI: 165, 171]) were included. Disease duration was 7.0 years [95% CI: 5.7, 8.2] and duration of the current episode was 3.1 months [95% CI: 1.7, 4.4]. Proportion of patients with prior resection was 42% [95% CI: 34%, 50%]. The disease was 21% in the ileum, 61% in ileocecum, and 18% in the colon. Budesonide dose was 8.83 mg/d [95% CI: 7.52, 10.14]. In a follow‐up duration of 21.0 weeks [95% CI: 15.2, 26.8], budesonide treatment was associated with improvement in CDAI score of −117.8 [95% CI: −134.0, −102.0]. The magnitude of the change in CDAI score at the latest follow‐up was significantly inversely associated with the percentage of smokers, but positively associated with the baseline CDAI score and duration of the current episode. Conclusion: Budesonide therapy to Crohn's disease patients appears to be more effective in patients with the more serious condition. Smoking may also affect the prognosis. Abstract : With the aim of identifying factors that can affect the prognosis of budesonide therapy for patients with Crohn's disease, we conducted this analysis using identified literature with strict predetermined criteria. We report here that change in the Crohn's disease activity (CDAI) index score change, particularly its magnitude, inversely associates with the percentage of smokers, but positively associated with the baseline CDAI score and duration of the current episode. Our results also indicate that budesonide therapy to Crohn's disease is more effective in advance patients with more serious conditions.