Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride. Issue 37 (8th April 2021)

• Record Type: Journal Article
• Authors: Zhang, Yiyuan; Chen, Wanting; Tan, Tingting; Gu, Yuang; Zhang, Shuning; Li, Jie; Wang, Yan; Hou, Wei; Yang, Guang; Ma, Peixiang; Xu, Hongtao
• Is Part Of: Chemical communications. Volume 57:Issue 37(2021)
• Page Start: 4588
• Page End: 4591
• Publication Date: 2021-04-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00769f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A one-pot palladium-catalyzed procedure for the synthesis of aryl phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. Abstract : We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitivity. The utility of this procedure has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for a DNA-encoded library (DEL).