A three-component iodine-catalyzed oxidative coupling reaction: a heterodifunctionalization of 3-methylindoles. Issue 26 (10th June 2021)

• Record Type: Journal Article
• Authors: Zhang, Wei; Xiang, Shiqun; Fan, Weibin; Jin, Jiang; Li, Yinghua; Huang, Deguang
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 26(2021)
• Page Start: 5794
• Page End: 5799
• Publication Date: 2021-06-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00730k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel method is reported for the heterodifunctionalization of 3-methylindoles in a TBHP/KI catalytic system with tert -butyl peroxy bonding to the indole skeleton as a functional group. Abstract : A metal-free method for the synthesis of heterodifunctional indole derivatives is developed through TBHP/KI-mediated oxidative coupling. The reaction constructs C–O and C–C bonds in succession with the help of tert -butyl peroxy radicals generated by the TBHP/KI catalytic system, enabling the direct realization of the heterodifunctionalization of indole in one pot. The product of this reaction is a novel heterodifunctional compound. This work might provide a new effective method for the synthesis of polycyclic indole compounds.