Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device. Issue 32 (22nd March 2021)

• Record Type: Journal Article
• Authors: Lin, Qing; Cai, Shijun; Zhou, Bing; Wang, Kemin; Jian, Lixin; Huang, Jin
• Is Part Of: Chemical communications. Volume 57:Issue 32(2021)
• Page Start: 3873
• Page End: 3876
• Publication Date: 2021-03-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00818h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A DNA-tetrahedron-based ''AND'' logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate computation cascades that produce 1 O2 in live cells, resulting in the death of target cells. Abstract : Endogenous miRNA expression patterns are extremely cell-type-specific, thereby offering high prediction accuracy for different cell identities. Here, a DNA-tetrahedron-based "AND" logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate a computation cascade that produces controlled singlet oxygen in live cells, resulting in the death of the target cell.