An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay. Issue 74 (26th August 2021)

• Record Type: Journal Article
• Authors: Lee, Suji; Han, Min Su
• Is Part Of: Chemical communications. Volume 57:Issue 74(2021)
• Page Start: 9450
• Page End: 9453
• Publication Date: 2021-08-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03638f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report the design and evaluation of an analyte-activatable artificial peroxidase system that allows the expansion of the applicability of the peroxidase activity-based sensing platform for the detection of a wide range of analytes. Abstract : We described an analyte-activatable artificial peroxidase system (caged Mn2 (bpmp)) by caging a dimanganese complex, exhibiting peroxidase-like activity, with an analyte-reactive trigger. It allowed adjustments of the detection target to be applied depending on the trigger as well as the detection modes, such as fluorescence and colorimetric, as required. This system was successfully applied to a versatile enzyme assay for leucine aminopeptidase and γ-glutamyl transpeptidase based on spectrophotometric change induced from the oxidation of the peroxidase substrate by analyte-triggered peroxidase-like activity.