3-Hydroxyflavone derivatives: promising scaffolds for fluorescent imaging in cells. Issue 46 (27th August 2021)
- Record Type:
- Journal Article
- Title:
- 3-Hydroxyflavone derivatives: promising scaffolds for fluorescent imaging in cells. Issue 46 (27th August 2021)
- Main Title:
- 3-Hydroxyflavone derivatives: promising scaffolds for fluorescent imaging in cells
- Authors:
- Zhao, Xueke
Li, Xiang
Liang, Shuyu
Dong, Xiongwei
Zhang, Zhe - Abstract:
- Abstract : Considering that biological macromolecules offer hydrophobic microenvironment, 3HF is a promising scaffold for the development of fluorescent imaging in cells. Abstract : As a typical class of excited-state intramolecular proton transfer (ESIPT) molecules, 3-hydroxyflavone derivatives (3HF, also known as flavonols) have received much attention recently. Thereinto, the role of hydrophobic microenvironment is significant importance in promoting the process and effects of ESIPT, which can be regulated by the solvents, the existence of metal ions and proteins rich with α-helix structures or the advanced DNA structures. Considering that plenty of biological macromolecules offer cellular hydrophobic microenvironment, enhancing the ESIPT effects and resulting in dual emission, 3HF could be a promising scaffold for the development of fluorescent imaging in cells. Furthermore, as the widespread occurance of compounds with biological activity in plants, 3HF derivatives are much more secure to be cellular diagnosis and treatment integrated fluorescent probes. In this review, multiple regulatory strategies for the fluorescence emission of 3HF derivatives have been collectively and comprehensively analyzed, including the solvent effects, metal chelation, interaction with proteins or DNAs, which would be beneficial for ESIPT-promoting or ESIPT-blocking processes and then enhance or control the fluorescence emission of 3HF effectively. We expect that this review would provide aAbstract : Considering that biological macromolecules offer hydrophobic microenvironment, 3HF is a promising scaffold for the development of fluorescent imaging in cells. Abstract : As a typical class of excited-state intramolecular proton transfer (ESIPT) molecules, 3-hydroxyflavone derivatives (3HF, also known as flavonols) have received much attention recently. Thereinto, the role of hydrophobic microenvironment is significant importance in promoting the process and effects of ESIPT, which can be regulated by the solvents, the existence of metal ions and proteins rich with α-helix structures or the advanced DNA structures. Considering that plenty of biological macromolecules offer cellular hydrophobic microenvironment, enhancing the ESIPT effects and resulting in dual emission, 3HF could be a promising scaffold for the development of fluorescent imaging in cells. Furthermore, as the widespread occurance of compounds with biological activity in plants, 3HF derivatives are much more secure to be cellular diagnosis and treatment integrated fluorescent probes. In this review, multiple regulatory strategies for the fluorescence emission of 3HF derivatives have been collectively and comprehensively analyzed, including the solvent effects, metal chelation, interaction with proteins or DNAs, which would be beneficial for ESIPT-promoting or ESIPT-blocking processes and then enhance or control the fluorescence emission of 3HF effectively. We expect that this review would provide a new perspective to develop novel 3HF-based fluorescent sensors for imaging in cells and plants. … (more)
- Is Part Of:
- RSC advances. Volume 11:Issue 46(2021)
- Journal:
- RSC advances
- Issue:
- Volume 11:Issue 46(2021)
- Issue Display:
- Volume 11, Issue 46 (2021)
- Year:
- 2021
- Volume:
- 11
- Issue:
- 46
- Issue Sort Value:
- 2021-0011-0046-0000
- Page Start:
- 28851
- Page End:
- 28862
- Publication Date:
- 2021-08-27
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1ra04767a ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 26742.xml