Safety Assessment of Silylates and Surface-Modified Siloxysilicates. (May 2013)

• Record Type: Journal Article
• Authors: Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan
• Other Names: Andersen F. Alan guest-editor.
• Is Part Of: International journal of toxicology. Volume 32:Number 3(2013)Supplement
• Page Start: 5S
• Page End: 24S
• Publication Date: 2013-05
• Subjects: silylates; Toxicology -- Periodicals; 615.9005
• DOI: 10.1177/1091581813486299
• Languages: English
• ISSNs: 1091-5818

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents—emollient, skin-conditioning agents—occlusive, slip modifiers, suspension agents—nonsurfactant, and viscosity increasing agents—nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.