Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery. Issue 55 (18th June 2021)

• Record Type: Journal Article
• Authors: Kim, Hyun-Soo; Lee, Yeongju; Shin, Min Hyeon; Lim, Hyun-Suk
• Is Part Of: Chemical communications. Volume 57:Issue 55(2021)
• Page Start: 6800
• Page End: 6803
• Publication Date: 2021-06-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02848k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. Abstract : Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine linear peptoids. The amphipathic cyclic peptoids showed an order of magnitude more efficient intracellular delivery ability, compared to a commonly used polyarginine cell-penetrating peptide, representing one of the best molecular transporters reported to date. Given the excellent cell-permeability, proteolytic stability, and ease of synthesis, the amphipathic cyclic peptoids would be broadly applicable to a wide range of clinical and biological applications.