Surgical Complications in a Multicenter Randomized Trial Comparing Preoperative Chemoradiotherapy and Immediate Surgery in Patients With Resectable and Borderline Resectable Pancreatic Cancer (PREOPANC Trial). Issue 5 (12th May 2022)

• Record Type: Journal Article
• Authors: van Dongen, Jelle C.; Suker, Mustafa; Versteijne, Eva; Bonsing, Bert A.; Mieog, J. Sven D.; de Vos-Geelen, Judith; van der Harst, Erwin; Patijn, Gijs A.; de Hingh, Ignace H.; Festen, Sebastiaan; Ten Tije, Albert J.; Busch, Olivier R.; Besselink, Marc G.; van Tienhoven, Geertjan; Koerkamp, Bas Groot; van Eijck, Casper H. J.
• Other Names: collaborator.
• Is Part Of: Annals of surgery. Volume 275:Issue 5(2022)
• Page Start: 979
• Page End: 984
• Publication Date: 2022-05-12
• Subjects: neoadjuvant therapy -- pancreas -- pancreatic cancer -- pancreatic neoplasm -- postoperative complications -- postoperative morbidity -- postoperative mortality -- postoperative pancreatic fistula -- preoperative chemoradiotherapy -- preoperative therapy -- surgical complications; Surgery -- Periodicals; 617.005
• DOI: 10.1097/SLA.0000000000004313
• Languages: English
• ISSNs: 0003-4932

Abstract

Abstract : Objectives: To investigate the effect of preoperative chemoradiotherapy on surgical complications in patients after pancreatic resection for (borderline-)resectable pancreatic cancer. Summary of Background Data: Preoperative chemoradiotherapy is increasingly used in patients with (borderline-)resectable pancreatic cancer. concerns have been raised about the potential harmful effect of any preoperative therapy on the surgical complication rate after pancreatic resection. Methods: An observational analysis was performed within the multicenter randomized controlled PREOPANC trial (April 2013–July 2017). The trial randomly assigned (1:1) patients to preoperative chemoradiotherapy followed by surgery and the remaining adjuvant chemotherapy or to immediate surgery, followed by adjuvant chemotherapy. The main analysis consisted of a per-protocol approach. The endpoints of the present analyses were the rate of postoperative complications. Results: This study included 246 patients from 16 centers, of whom 66 patients underwent resection after preoperative therapy and 98 patients after immediate surgery. No differences were found regarding major complications (37.9% vs 30.6%, P =0.400), postpancreatectomy hemorrhage (9.1% vs 5.1%, P =0.352), delayed gastric emptying (21.2% vs 22.4%, P =0.930), bile leakage (4.5% vs 3.1%, P =0.686), intra-abdominal infections (12.1% vs 10.2%, P =0.800), and mortality (3.0% vs 4.1%, P =1.000). There was a significant lower incidence of postoperative pancreatic fistula in patients who received preoperative chemoradiotherapy (0% vs 9.2%, P =0.011). Conclusions: Preoperative chemoradiotherapy did not increase the incidence of surgical complications or mortality and reduced the rate of postoperative pancreatic fistula after resection in patients with (borderline-)resectable pancreatic cancer.