Aquaporins and diseases pathogenesis: From trivial to undeniable involvements, a disease‐based point of view. Issue 9 (8th February 2021)

• Record Type: Journal Article
• Authors: Ala, Moein; Mohammad Jafari, Razieh; Hajiabbasi, Asghar; Dehpour, Ahmad Reza
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 9(2021)
• Page Start: 6115
• Page End: 6135
• Publication Date: 2021-02-08
• Subjects: ADPKD -- aquaporins -- inflammation -- Meniere's disease -- pemphigoid bullous -- vasopressin -- water channels; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30318
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Aquaporins (AQPs), as transmembrane proteins, were primarily identified as water channels with the ability of regulating the transmission of water, glycerol, urea, and other small‐sized molecules. The classic view of AQPs involvement in therapeutic plan restricted them and their regulators into managing only a narrow spectrum of the diseases such as diabetes insipidus and the syndrome of inappropriate ADH secretion. However, further investigations performed, especially in the third millennium, has found that their cooperation in water transmission control can be manipulated to handle other burden‐imposing diseases such as cirrhosis, heart failure, Meniere's disease, cancer, bullous pemphigoid, eczema, and Sjögren's syndrome. Abstract : Aquaporins (AQPs) participation in different pathophysiological states including; encephalopathy, inflammation, neuromyelitis optica (NMO), heart failure, cancer, Meniere's disease, ADPKD, syndrome of inappropriate ADH secretion (SIADH), Sjögren's syndrome, bullous pemphigoid, eczema, psoriasis, pruritus, cystic fibrosis, cirrhosis, constipation, and diarrhea.