Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders. (4th May 2023)

• Record Type: Journal Article
• Authors: Chen, Chen; Ai, Qidi; Shi, Axi; Wang, Nan; Wang, Lina; Wei, Yuhui
• Is Part Of: Nutritional neuroscience. Volume 26:Number 5(2023)
• Page Start: 414
• Page End: 428
• Publication Date: 2023-05-04
• Subjects: Oleanolic acid -- Ursolic acid -- neurodegenerative disease -- neuropsychiatric disease -- brain disorder -- neurological disease -- natural product -- phytochemical; Neuropharmacology -- Periodicals; Diet -- Periodicals; Diet therapy -- Periodicals; Nutrition -- Periodicals; 615.78
• DOI: 10.1080/1028415X.2022.2051957
• Languages: English
• ISSNs: 1028-415X

Abstract

ABSTRACT: Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in various plant foods and Chinese herbal medicines. Accumulating evidence indicates that OA and UA exhibit neuroprotective effects on multiple brain disorders. Therefore, this paper reviews researches of OA and UA on neurodegenerative diseases, neuropsychiatric diseases and other brain disorders including ischemic stroke, epilepsy, etc, as well as the potential underlying molecular mechanisms. GRAPHICAL ABSTRACT: UF0001