The oncogenic and tumor suppressive roles of RNA‐binding proteins in human cancers. Issue 9 (8th February 2021)

• Record Type: Journal Article
• Authors: Bitaraf, Amirreza; Razmara, Ehsan; Bakhshinejad, Babak; Yousefi, Hassan; Vatanmakanian, Mousa; Garshasbi, Masoud; Cho, William C.; Babashah, Sadegh
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 9(2021)
• Page Start: 6200
• Page End: 6224
• Publication Date: 2021-02-08
• Subjects: cancer -- lncRNA -- microRNA -- posttranscriptional regulation -- RNA‐binding proteins; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30311
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Posttranscriptional regulation is a mechanism for the cells to control gene regulation at the RNA level. In this process, RNA‐binding proteins (RBPs) play central roles and orchestrate the function of RNA molecules in multiple steps. Accumulating evidence has shown that the aberrant regulation of RBPs makes contributions to the initiation and progression of tumorigenesis via numerous mechanisms such as genetic changes, epigenetic alterations, and noncoding RNA‐mediated regulations. In this article, we review the effects caused by RBPs and their functional diversity in the malignant transformation of cancer cells that occurs through the involvement of these proteins in various stages of RNA regulation including alternative splicing, stability, polyadenylation, localization, and translation. Besides this, we review the various interactions between RBPs and other crucial posttranscriptional regulators such as microRNAs and long noncoding RNAs in the pathogenesis of cancer. Finally, we discuss the potential approaches for targeting RBPs in human cancers. Abstract : RNA‐binding proteins (RBPs) play central roles in posttranscriptional regulation during normal physiology and cancer pathogenicity. In this article, we review the effects caused by RBPs and their functional diversity in the malignant transformation of cancer cells that occurs through the involvement of these proteins in various stages of RNA regulation.