Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors. Issue 24 (28th October 2021)

• Record Type: Journal Article
• Authors: Steiger, Christoph; Phan, Nhi V.; Huang, Hen‐Wei; Sun, Haoying; Chu, Jacqueline N.; Reker, Daniel; Gwynne, Declan; Collins, Joy; Tamang, Siddartha; McManus, Rebecca; Lopes, Aaron; Hayward, Alison; Baron, Rebecca M.; Kim, Edy Y.; Traverso, Giovanni
• Is Part Of: Advanced science. Volume 8:Issue 24(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-28
• Subjects: biomarker monitoring -- continuous monitoring -- gastric sensors -- nasogastric tubes; Science -- Periodicals; 505
• DOI: 10.1002/advs.202102861
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Continuous monitoring in the intensive care setting has transformed the capacity to rapidly respond with interventions for patients in extremis. Noninvasive monitoring has generally been limited to transdermal or intravascular systems coupled to transducers including oxygen saturation or pressure. Here it is hypothesized that gastric fluid (GF) and gases, accessible through nasogastric (NG) tubes, commonly found in intensive care settings, can provide continuous access to a broad range of biomarkers. A broad characterization of biomarkers in swine GF coupled to time‐matched serum is conducted . The relationship and kinetics of GF‐derived analyte level dynamics is established by correlating these to serum levels in an acute renal failure and an inducible stress model performed in swine. The ability to monitor ketone levels and an inhaled anaesthetic agent (isoflurane) in vivo is demonstrated with novel NG‐compatible sensor systems in swine. Gastric access remains a main stay in the care of the critically ill patient, and here the potential is established to harness this establishes route for analyte evaluation for clinical management. Abstract : Nasogastric tube placement in intensive care settings is a mainstay in the management of critical conditions. The authors demonstrate that systemic biomarkers are present in gastric fluid and that nasogastric tubes can be leveraged to monitor systemic disturbances through evaluation of these biomarkers. Real‐time biomarker monitoring can help improve responsiveness of clinical teams and improve critical care.