Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study. Issue 1 (31st January 2022)

• Record Type: Journal Article
• Authors: Wanlapakorn, Nasamon; Suntronwong, Nungruthai; Phowatthanasathian, Harit; Yorsaeng, Ritthideach; Vichaiwattana, Preeyaporn; Thongmee, Thanunrat; Auphimai, Chompoonut; Srimuan, Donchida; Thatsanatorn, Thaksaporn; Assawakosri, Suvichada; Kanokudom, Sitthichai; Poovorawan, Yong
• Is Part Of: Human vaccines & immunotherapeutics. Volume 18:Issue 1(2022)
• Publication Date: 2022-01-31
• Subjects: Heterologous -- homologous -- inactivated -- COVID-19 -- vaccine -- viral vectored -- adults; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2022.2029111
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: In light of intermittent supply shortages of individual vaccines and evidence of rare but serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines have gained significant interest. This study aims to assess the reactogenicity and immunogenicity of the heterologous adenoviral vector (ChAdOx1-S, AstraZeneca; hereafter referred to as AZ) and the inactivated vaccine regimen (CoronaVac; hereafter referred to as CV) in healthy Thai adults immunized between June and September 2021. Our study showed that adverse events following homologous CV-CV and AZ-AZ, and heterologous CV-AZ and AZ-CV combinations, were mild and well tolerated overall. Receptor-binding domain (RBD)-specific antibody responses and neutralizing activities against wild-type and variants of concern after two-dose vaccination were higher in the heterologous CV-AZ and homologous AZ-AZ groups compared to the CV-CV and AZ-CV groups. Conversely, the spike-specific IgA response was detected only in the CV-AZ group after two doses of vaccination. The total interferon gamma response was detected in both the CV-AZ and AZ-CV groups after the two-dose vaccination. Given the shorter completion time of two doses, heterologous CoronaVac followed by ChAdOx1-S can be considered as an alternative regimen to homologous efficacy-proven ChAdOx1-S in countries with circulating variants. Additional studies on the efficacy and durability of immune responses induced by heterologous vaccine regimens are warranted.