A review on electronic nose for diagnosis and monitoring treatment response in lung cancer. (1st April 2023)

• Record Type: Journal Article
• Authors: Vadala, Rohit; Pattnaik, Bijay; Bangaru, Sunil; Rai, Divyanjali; Tak, Jaya; Kashyap, Seetu; Verma, Umashankar; Yadav, Geetika; Dhaliwal, RS; Mittal, Saurabh; Hadda, Vijay; Madan, Karan; Guleria, Randeep; Agrawal, Anurag; Mohan, Anant
• Is Part Of: Journal of breath research. Volume 17:Number 2(2023)
• Publication Date: 2023-04-01
• Subjects: lung cancer -- exhaled breath analysis -- VOCs -- eNOSE -- biomarker; Volatile organic compounds -- Analysis -- Periodicals; Clinical chemistry -- Periodicals; Bad breath -- Periodicals; Bad breath -- Treatment -- Periodicals; Bad breath -- Diagnosis -- Periodicals; 616.0756
• DOI: 10.1088/1752-7163/acb791
• Languages: English
• ISSNs: 1752-7155

Abstract

Abstract: Lung cancer is one of the common malignancies with high mortality rate and a poor prognosis. Most lung cancer cases are diagnosed at an advanced stage either due to limited resources of infrastructure, trained human resources, or delay in clinical suspicion. Low-dose computed tomography has emerged as a screening tool for lung cancer detection but this may not be a feasible option for most developing countries. Electronic nose is a unique non-invasive device that has been developed for lung cancer diagnosis and monitoring response by exhaled breath analysis of volatile organic compounds. The breath-print have been shown to differ not only among lung cancer and other respiratory diseases, but also between various types of lung cancer. Hence, we postulate that the breath-print analysis by electronic nose could be a potential biomarker for the early detection of lung cancer along with monitoring treatment response in a resource-limited setting. In this review, we have consolidated the current published literature suggesting the use of an electronic nose in the diagnosis and monitoring treatment response of lung cancer.