Steroidal alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their anti-inflammatory activities. (May 2023)

• Record Type: Journal Article
• Authors: Wang, Shu-Hui; Wang, Yu-Qi; Wang, Qi-Qi; Wang, Le; Zhang, Qing-Ying; Tu, Peng-Fei
• Is Part Of: Phytochemistry. Volume 209(2023)
• Publication Date: 2023-05
• Subjects: Fritillaria unibracteata var -- Wabuensis (S. Y. tang & S. C. yueh) Z -- D -- Liu -- Shu wang & S. C. chen -- Liliaceae -- Chuan bei-mu -- Steroidal alkaloids -- Anti-inflammation; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2023.113640
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Fourteen previously undescribed steroidal alkaloids, including six jervine-type, wabujervine A-E and wabujerside A, seven cevanine-type, wabucevanine A-G, and one secolanidin-type, wabusesolanine A, along with thirteen known steroidal alkaloids, were isolated from the bulbs of Fritillaria unibracteata var. wabuensis . On the basis of comprehensive analysis of IR, HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses, their structures were elucidated. In the zebrafish acute inflammatory models, nine compounds showed anti-inflammatory activity. Graphical abstract: Image 1 Highlights: Fourteen undescribed steroidal alkaloids were isolated from the bulbs of Fritillaria unibracteata var. wabuensis. Two jervine-type steroidal alkaloids possess an unusual cis A/B ring system. Nine steroidal alkaloids displayed anti-inflammatory activity in a CuSO4 -induced transgenic zebrafish model.